Dessislava Kopchaliiska, Ph.D., D (ABHI), is an Assistant
Adjunct Professor specializing in immunogenetics and
histocompatibility and Diplomate of the ABHI (American Board of
Histocompatibility and Immunogenetics).
Dr. Kopchaliiska graduated with a B.S. in Biotechnology from the
University of Sofia in Bulgaria. She obtained her Ph.D. at the
Bulgarian Academy of Sciences, and she was a Postdoctoral Fellow in
Immunogenetics and Transplantation Immunology at Johns Hopkins
University School of Medicine.
Dr. Kopchaliiska has been the recipient of several awards
including the American Society for Histocompatibility and
Immunogenetics Scholar Award and The Sofia University, Alumni
Association, Professional Achievement Award.
She is also a member of numerous professional
organizations including the American Society for Histocompatibility
and Immunogenetics, American Association of Immunologists and the
Johns Hopkins Medical and Surgical Association.
My research interests are focused on identification and
characterization of HLA-specific B cells in transplant patients. I
have developed an assay for the identification and quantification
of HLA-specific B lymphocytes using HLA tetramers. Patients with
known sensitization to HLA have significantly higher frequencies of
B cells specific for the antigen(s) to which they were exposed
compared to healthy, non-sensitized males. Additionally,
after induction in vitro of the HLA-specific B cells with a
combination of cytokines and polyclonal stimuli, they produce
antibodies of the respective HLA specificity. My further studies
will be focused on characterization of the different subpopulations
of HLA-specific B cells and their role in transplant
Sikorski P, Kopchaliiska D, Lucas DP, Leffell MS, Zachary AA.
Characterization of an antibody specific for HLA-A36 and not
reactive with HLA-A1, Hum Immunol. 72(1):87-90, 2011.
Zachary AA, Kopchaliiska D, Jackson AM, Leffell MS.
Immunogenetics and immunology in transplantation, Immunol Res.
Kopchaliiska D, Zachary AA, Montgomery RA, Leffell MS:
Reconstitution of peripheral allospecific CD19+ B-cell subsets
after B-lymphocyte depletion therapy in renal transplant patients.
Transplantation, Vol. 87(9), 2009.
Zachary AA, Kopchaliiska D, Montgomery RA, Leffell MS:
HLA-specific B cells: I. A method for their detection,
quantification, and isolation using HLA tetramers, Transplantation,
Vol. 83, 2007.
Zachary AA, Kopchaliiska D, Montgomery RA, Melancon JK, Leffell
MS: HLA-specific B cells: II. Application to transplantation,
Transplantation, Vol. 83, 2007.